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Caffeic Acid Phenethyl Ester Loaded in Microemulsions: Enhanced In Vitro Activity against Colon and Breast Cancer Cells and Possible Cellular Mechanisms

Published on Mar 1, 2019in Food Biophysics2.41
· DOI :10.1007/s11483-018-9559-y
Huaiqiong Chen11
Estimated H-index: 11
(UT: University of Tennessee),
Yongguang Guan11
Estimated H-index: 11
(UT: University of Tennessee)
+ 1 AuthorsQixin Zhong31
Estimated H-index: 31
(UT: University of Tennessee)
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Abstract
Caffeic acid phenethyl ester (CAPE) has high cytotoxicity against various cancer cells but has low water solubility and poor bioavailability. The objective of this work was to study a fully-dilutable oil-in-water microemulsion as a delivery vehicle of CAPE and the impacts on cellular uptake and expression of relevant proteins. Up to 3.30% w/w CAPE was dissolved in the microemulsion with droplets smaller than 20 nm and stable in 180 days. CAPE in the microemulsion had the significantly increased anti-proliferative activity against human HCT-116 colorectal and MCF-7 breast cancer cells than that in dimethyl sulfoxide. Dissolving CAPE in the microemulsion enhanced the cellular uptake according to fluorescence microscopy, flow cytometry, and HPLC. Subsequently, cyclin D1 was suppressed and p53 was induced, which regulated cell cycle and apoptosis, respectively, thereby enhancing anti-cancer activity. Findings from the present work suggest the potential of the studied microemulsion as a vehicle of CAPE for development of cancer intervention strategies.
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References49
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Published on Feb 22, 2017in Journal of Agricultural and Food Chemistry3.57
Maria Luisa Bondì17
Estimated H-index: 17
(University of Palermo),
Maria Rita Emma6
Estimated H-index: 6
+ 7 AuthorsMelchiorre Cervello36
Estimated H-index: 36
Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumoral activity of curcumin, by entrapping it into nanostructured lipid carriers (NLCs). For this purpo...
Published on Jan 1, 2017in European Journal of Pharmaceutical Sciences3.53
Faranak Dehghani2
Estimated H-index: 2
(FUM: Ferdowsi University of Mashhad),
Nafiseh Farhadian5
Estimated H-index: 5
(FUM: Ferdowsi University of Mashhad)
+ 3 AuthorsMohammad Karimi3
Estimated H-index: 3
(MUMS: Mashhad University of Medical Sciences)
Abstract The aim of this study was to prepare and characterize a new nanocarrier for oral delivery of tamoxifen citrate (TMC) as a lipophilic oral administrated drug. This drug has low oral bioavailability due to its low aqueous solubility. To enhance the solubility of this drug, the microemulsion system was applied in form of oil-in-water. Sesame oil and Tween 80 were used as drug solvent oil and surfactant, respectively. Two different formulations were prepared for this purpose. The first form...
Published on Jan 1, 2017in RSC Advances3.05
Tao Wang5
Estimated H-index: 5
,
Huaiqiong Chen11
Estimated H-index: 11
(UT: University of Tennessee)
+ 2 AuthorsQixin Zhong31
Estimated H-index: 31
(UT: University of Tennessee)
The self-emulsification of oils containing dissolved solutes is not only an intriguing phenomenon but is also of practical interest in the delivery of agricultural chemicals and drugs. Herein, a facile one-step self-emulsification of eugenol with tunable release rates of encapsulated lipophilic compounds was enabled simply by gently mixing eugenol with modified rice proteins (MRPs). Due to binding with eugenol by hydrophobic interactions lowering the oil/water interfacial tension, MRPs underwent...
Published on Jan 1, 2017in RSC Advances3.05
Tao Wang5
Estimated H-index: 5
,
Ren Wang11
Estimated H-index: 11
(Jiangnan University)
+ 1 AuthorsQixin Zhong31
Estimated H-index: 31
(UT: University of Tennessee)
Fabrication of manipulative colloidal vehicles with appreciable stability under an eco-friendly, cross-linkage free environment has long been one of the major challenges in targeted delivery for curative, acoustic, and imaging purposes. A new targeted delivery system was developed in this paper based on magnetization of eugenol with magnetic Fe3O4 nanoparticles by simply evaporating water from the 3-phase system prior to a one-step coating of the oil using rice proteins to form core/shell struct...
Published on Jan 1, 2017in International Journal of Food Microbiology4.01
Campana Raffaella1
Estimated H-index: 1
(University of Urbino),
Luca Casettari16
Estimated H-index: 16
(University of Urbino)
+ 3 AuthorsWally Baffone20
Estimated H-index: 20
(University of Urbino)
Abstract Food safety is a fundamental concern for both consumers and the food industry, especially as the numbers of reported cases of food-associated infections continue to increase. Industrial surfaces can provide a suitable substrate for the development and persistence of bacterial organized in biofilms that represent a potential source of food contamination. The negative consumer perception of chemical disinfectants has shifted the attention to natural substances, such as plant extracts. The...
Published on Aug 17, 2016in Journal of Agricultural and Food Chemistry3.57
Rui Xue Guo1
Estimated H-index: 1
,
Xiong Fu27
Estimated H-index: 27
+ 2 AuthorsGu Chen16
Estimated H-index: 16
To improve the bioactivity and oral bioavailability of myricetin, a microemulsion formulation was successfully developed, which consisted of Cremophor RH40 (12%), Tween 80 (6%), Transcutol HP (9%), WL 1349 (18%), and distilled water (55%). With lower content of surfactants and higher stability after dilution and storage for 6 months, the optimized myricetin microemulsion (MYR-ME) could dramatically enhance the solubility of myricetin 1225 times that in water. MYR-ME significantly increased antip...
Published on Aug 1, 2016in Food Chemistry5.40
Zhenbo Xu2
Estimated H-index: 2
(Jiangnan University),
Jun Jin5
Estimated H-index: 5
(Jiangnan University)
+ 4 AuthorsXingguo Wang26
Estimated H-index: 26
(Jiangnan University)
Abstract The aim of the study is to prepare co-surfactant free microalgal oil microemulsions and investigate their properties as well as processing stability for food application. The physicochemical characteristics of the microemulsions were investigated by dynamic light scattering (DLS), turbidity, conductivity, rheological measurements and transmission electron microscopy (TEM). Within the microemulsion region, when the surfactant to oil ratio was 9:1, the hydrodynamic diameter ( D h ) was 18...
Published on May 1, 2016in Life Sciences3.45
Pakin Sukamporn2
Estimated H-index: 2
(MU: Mahidol University),
Pleumchitt Rojanapanthu7
Estimated H-index: 7
(Thammasat University)
+ 3 AuthorsSeung Joon Baek43
Estimated H-index: 43
(UT: University of Tennessee)
Abstract Aims Damnacanthal is an anthraquinone isolated from the root of Morinda citrifolia L. (noni), and it exhibits many pharmacological properties, including anti-cancer activity. Damnacanthal targets several signal transduction proteins related to cell growth inhibition or apoptosis. However, the molecular mechanisms by which damnacanthal affects cell cycle regulation have not been elucidated in detail. Main methods Cyclin D1 is an important regulatory protein in cell cycle progression and ...
Kun Tong4
Estimated H-index: 4
(SDU: Shandong University),
Chunhua Zhao1
Estimated H-index: 1
(China Oilfield Services),
Dejun Sun27
Estimated H-index: 27
(SDU: Shandong University)
Abstract The preparation of nanoemulsions using long chain oil (C 20 to C 33 ) with remarkably small droplet size by microemulsion dilution method is generally difficult. In this work, a simple, W/O microemulsion dilution method was used to prepare O/W nanoemulsions with long chain oil in water/Span 80 − Tween 80/paraffin system. With the increase of dilution temperature from 40 to 80 °C, the emulsion droplet diameter decreased from 1.2 μm to 61 nm. The increase in the amount of dilution water l...
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