SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high‐fat feeding
Abstract
Key points Maternal high‐fat diet (MHF) consumption led to metabolic and liver disorders in male offspring, which are associated with reduced sirtuin (SIRT)1 expression and activity in the offspring liver SIRT1 overexpression in MHF offspring reduced their body weight and adiposity and normalized lipid metabolic markers in epididymal and retroperitoneal adipose tissues SIRT1 overexpression in MHF offspring improved glucose tolerance, as well as...
Paper Details
Title
SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high‐fat feeding
Published Date
Oct 31, 2018
Journal
Volume
597
Issue
2
Pages
467 - 480
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