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Gold nanoparticles as cell regulators: beneficial effects of gold nanoparticles on the metabolic profile of mice with pre-existing obesity

Published on Dec 1, 2018in Journal of Nanobiotechnology 5.34
· DOI :10.1186/s12951-018-0414-6
Hui Chen21
Estimated H-index: 21
(UTS: University of Technology, Sydney),
Jane P. M. Ng1
Estimated H-index: 1
(UTS: University of Technology, Sydney)
+ 2 AuthorsStella M. Valenzuela26
Estimated H-index: 26
(UTS: University of Technology, Sydney)
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Abstract
Background We have previously shown that intraperitoneal injection of gold nanoparticles (AuNPs, 20–30 nm) into mice, decreases high-fat diet (HFD) induced weight gain and glucose intolerance, via suppression of inflammatory responses in both fat and liver tissues. This study investigates whether AuNPs provide similar benefit to mice with pre-existing obesity. Male C57BL/6 mice were fed a HFD for 15 weeks. AuNPs (OB-EAu 0.0785 μg/g/day, OB-LAu 0.785 μg/g/day, OB-HAu7.85 μg/g/day, ip) were administered to subgroups of HFD-fed mice over the last 5 weeks. Control group was fed standard chow and administered vehicle injection.
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Published on Dec 1, 2018in Journal of Nanobiotechnology 5.34
Hui Chen21
Estimated H-index: 21
(UTS: University of Technology, Sydney),
Jane P. M. Ng1
Estimated H-index: 1
(UTS: University of Technology, Sydney)
+ 7 AuthorsStella M. Valenzuela26
Estimated H-index: 26
(UTS: University of Technology, Sydney)
Background Obesity is a high risk for multiple metabolic disorders due to excessive influx of energy, glucose and lipid, often from a western based diet. Low-grade inflammation plays a key role in the progression of such metabolic disorders. The anti-inflammatory property of gold compounds has been used in treating rheumatoid arthritis in the clinic. Previously we found that pure gold nanoparticles (AuNPs, 21 nm) also possess anti-inflammatory effects on the retroperitoneal fat tissue following ...
2 Citations Source Cite
Published on Nov 1, 2018in Colloids and Surfaces B: Biointerfaces 3.97
Laura Rodriguez-Lorenzo21
Estimated H-index: 21
(University of Fribourg),
Sarah Rafiee1
Estimated H-index: 1
(University of Fribourg)
+ 6 AuthorsAlke Petri-Fink31
Estimated H-index: 31
(University of Fribourg)
Abstract The lack of understanding of fundamental nano-bio interactions, and difficulties in designing particles stable in complex biological environments are major limitations to their translation into biomedical clinical applications. Here we present a multi-parametric approach to fully characterize targeted nanoparticles, and emphasizes the significant effect that each detail in the synthetic process can have on downstream in vitro results. Through an iterative process, particles were designe...
1 Citations Source Cite
Sonia Saad18
Estimated H-index: 18
(Kolling Institute of Medical Research),
Ibrahim Al-Odat6
Estimated H-index: 6
(Jadara University)
+ 4 AuthorsHui Chen21
Estimated H-index: 21
(CDUTCM: Chengdu University of Traditional Chinese Medicine)
2 Citations Source Cite
Published on Jan 1, 2018in Analytical Methods 2.38
David P. Bishop13
Estimated H-index: 13
(UTS: University of Technology, Sydney),
Mandy Grossgarten1
Estimated H-index: 1
(WWU: University of Münster)
+ 6 AuthorsUwe Karst44
Estimated H-index: 44
(WWU: University of Münster)
The likelihood of exposure to antimicrobial silver nanoparticles continues to grow with their increasing ubiquity in various medical and consumer products. While translocation of silver nanoparticles to major organs has been examined, the in situ location and concentration in the organs is not well characterised. Here we have used laser ablation-inductively coupled plasma-mass spectrometry to quantitatively image serial sections to construct a three-dimensional representation of the distribution...
2 Citations Source Cite
Published on Apr 1, 2017in International Journal of Nanomedicine 4.47
Van Hong Nguyen4
Estimated H-index: 4
,
Beom-Jin Lee29
Estimated H-index: 29
53 Citations Source Cite
Published on Aug 1, 2015in Diabetologia 7.11
Bo Ahrén87
Estimated H-index: 87
(Lund University)
Research conducted over the last 50 years has produced discoveries on the importance of glucose control for reducing the risk of diabetic complications, the pathophysiology of type 2 diabetes, the development and validation of mechanistic glucose-lowering targets, and the preclinical and clinical development of individual drugs. This science established the different drug classes that are clinically used today in association with lifestyle changes for lowering glucose in type 2 diabetes. For the...
7 Citations Source Cite
Published on May 6, 2015in Biofactors 3.60
Ryan Namiri-Kalantari2
Estimated H-index: 2
(UCLA: University of California, Los Angeles),
Feng Gao11
Estimated H-index: 11
(UCLA: University of California, Los Angeles)
+ 4 AuthorsSrinivasa T. Reddy58
Estimated H-index: 58
(UCLA: University of California, Los Angeles)
High density lipoprotein (HDL) has long been considered a protective factor against the development of coronary heart disease. Two important roles of HDL include reverse cholesterol transport (RCT) and the modulation of inflammation. The main protein component of HDL; apolipoprotein A-I (apo A-I) is primarily responsible for RCT. Apo A-I can be damaged by oxidative mechanisms, which reduce the protein's ability to promote RCT. In disease states such as diabetes, associated with a chronic acute-p...
13 Citations Source Cite
Published on Aug 1, 2014in Inflammation 2.94
Giorgio Ghigliotti18
Estimated H-index: 18
(UniGe: University of Genoa),
Chiara Barisione13
Estimated H-index: 13
(UniGe: University of Genoa)
+ 9 AuthorsDomenico Palombo18
Estimated H-index: 18
(UniGe: University of Genoa)
Adipose tissue inflammation mediates the association between excessive body fat accumulation and several chronic inflammatory diseases. A high prevalence of obesity-associated adipose tissue inflammation was observed not only in patients with cardiovascular conditions but also in patients with inflammatory bowel diseases, abdominal aortic aneurysm, or cardiorenal syndrome. In addition to excessive caloric intake, other triggers promote visceral adipose tissue inflammation followed by chronic, lo...
76 Citations Source Cite
Published on Mar 1, 2014in Diabetologia 7.11
Hui Chen21
Estimated H-index: 21
(UNSW: University of New South Wales),
David Simar19
Estimated H-index: 19
(UNSW: University of New South Wales)
+ 3 AuthorsMargaret J. Morris48
Estimated H-index: 48
(UNSW: University of New South Wales)
Aims/hypothesis Maternal obesity leads to increased adiposity, hyperlipidaemia and glucose intolerance in offspring. The analogue of glucagon-like peptide-1, exendin-4 (Ex-4), has been shown to induce weight loss in both adolescence and adulthood. We hypothesised that, in rats, daily injection of Ex-4 would reduce body fat and improve metabolic disorders in offspring from obese dams, especially those consuming a high-fat diet (HFD).
20 Citations Source Cite
Published on Mar 1, 2014in Journal of Lipid Research 4.74
Kristine C.Y. McGrath17
Estimated H-index: 17
(UTS: University of Technology, Sydney),
Xiaohong Li6
Estimated H-index: 6
+ 7 AuthorsAlison K. Heather19
Estimated H-index: 19
(UTS: University of Technology, Sydney)
Obesity-induced liver inflammation can drive insulin resistance. HDL has anti-inflammatory properties, so we hypothesized that low levels of HDL would perpetuate inflammatory responses in the liver and that HDL treatment would suppress liver inflammation and insulin resistance. The aim of this study was to investigate the effects of lipid-free apoAI on hepatic inflammation and insulin resistance in mice. We also investigated apoAI as a component of reconstituted HDLs (rHDLs) in hepatocytes to co...
19 Citations Source Cite
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