Neutral tumor evolution?
Abstract
Williams et al. (Nat. Genet. 48:238-224, 2016) recently reported neutral tumor evolution in one third of 904 samples from The Cancer Genome Atlas. Here, we assess the reproducibility and validity of their method and the extent of positive selection in subclonal mutations across cancer types. Our results do not support observable neutral tumor evolution and uncover strong positive selection within subclonal mutations across...
Paper Details
Title
Neutral tumor evolution?
Published Date
Oct 29, 2018
Journal
Volume
50
Issue
12
Pages
1630 - 1633
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