In vitro distinction between proinflammatory and antiinflammatory macrophages with gadolinium‐liposomes and ultrasmall superparamagnetic iron oxide particles at 3.0T

Background Inflammation involves a heterogeneous macrophage population, for which there is no readily available MR assessment method. Purpose To assess the feasibility of distinguishing proinflammatory M1 and antiinflammatory M2 macrophages at MRI enhanced with gadolinium liposomes or ultrasmall superparamagnetic iron oxide particles. Study Type In vitro. Specimen We employed cultured RAW macrophages. M0 macrophages were polarized with...