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Pharmacotherapy of obesity: Available medications and drugs under investigation

Published on Mar 1, 2019in Metabolism-clinical and Experimental6.51
· DOI :10.1016/j.metabol.2018.10.010
Eleni Pilitsi1
Estimated H-index: 1
(BIDMC: Beth Israel Deaconess Medical Center),
Olivia M. Farr20
Estimated H-index: 20
(BIDMC: Beth Israel Deaconess Medical Center)
+ 4 AuthorsChristos S. Mantzoros106
Estimated H-index: 106
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract
Abstract Obesity is a chronic disease with a continuously rising prevalence that currently affects more than half a billion people worldwide. Energy balance and appetite are highly regulated via central and peripheral mechanisms, and weight loss triggers a homeostatic response leading to weight regain. Lifestyle and behavioral modifications are the cornerstones of obesity management; however, they often fail to achieve or sustain long-term weight loss. Pharmacotherapy added onto lifestyle modifications results in an additional, albeit limited, weight reduction. Regardless, this weight reduction of 5–10% conveys multiple cardiovascular and metabolic benefits. In this review, evidence on the food and drug administration (FDA)-approved medications, i.e., orlistat, lorcaserin, phentermine/topiramate, liraglutide and naltrexone/bupropion, is summarized. Furthermore, anti-obesity agents in the pipeline for potential future therapeutic use are presented.
  • References (278)
  • Citations (16)
References278
Newest
#1Ghadeer K. Dawwas (UF: University of Florida)H-Index: 3
#2Steven M. Smith (UF: University of Florida)H-Index: 12
Last.Haesuk Park (UF: University of Florida)H-Index: 13
view all 3 authors...
13 CitationsSource
#1Takashi Sasaki (Jikei University School of Medicine)H-Index: 14
#2Masahiro SugawaraH-Index: 2
Last.Masahiro FukudaH-Index: 11
view all 3 authors...
8 CitationsSource
#1Abhinav Sharma (U of A: University of Alberta)H-Index: 12
#2Andrew P. Ambrosy (Duke University)H-Index: 12
Last.Eric J. Velazquez (Duke University)H-Index: 57
view all 14 authors...
4 CitationsSource
#1Ariana M. Chao (UPenn: University of Pennsylvania)H-Index: 9
#2Thomas A. Wadden (UPenn: University of Pennsylvania)H-Index: 104
Last.Jena Shaw Tronieri (UPenn: University of Pennsylvania)H-Index: 4
view all 12 authors...
2 CitationsSource
#1Maartje S. Spetter (University of Tübingen)H-Index: 6
#2Gordon B. Feld (University of Tübingen)H-Index: 3
Last.Manfred Hallschmid (University of Tübingen)H-Index: 29
view all 6 authors...
12 CitationsSource
#1Brendon L. Neuen (UNSW: University of New South Wales)H-Index: 6
#2Toshiaki Ohkuma (UNSW: University of New South Wales)H-Index: 6
Last.Vlado Perkovic (UNSW: University of New South Wales)H-Index: 67
view all 14 authors...
41 CitationsSource
#1Silvia LeonH-Index: 13
#2Inmaculada Velasco (UCO: University of Córdoba (Spain))H-Index: 2
Last.Manuel Tena-SempereH-Index: 68
view all 15 authors...
2 CitationsSource
#1Philip Ambery (MedImmune)H-Index: 3
#2Sebastian Klammt (Charité)H-Index: 2
Last.Boaz Hirshberg (MedImmune)H-Index: 22
view all 8 authors...
5 CitationsSource
#1Merlin C. Thomas (Monash University)H-Index: 56
#2David Z.I. Cherney (U of T: University of Toronto)H-Index: 31
35 CitationsSource
#1Gema FrühbeckH-Index: 61
#2Javier Gómez-Ambrosi (University of Navarra)H-Index: 49
Last.Victoria Catalán (University of Navarra)H-Index: 35
view all 11 authors...
2 CitationsSource
Cited By16
Newest
#1Natia Peradze (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
Last.Christos S. Mantzoros (Harvard University)H-Index: 106
view all 6 authors...
Source
#1Ewa Bromek (PAN: Polish Academy of Sciences)H-Index: 9
#2Marta Rysz (PAN: Polish Academy of Sciences)H-Index: 5
Last.Władysława A. Daniel (PAN: Polish Academy of Sciences)H-Index: 22
view all 4 authors...
Source
#1S. Esakkimuthu (University of Madras)H-Index: 1
#2S. Nagulkumar (University of Madras)H-Index: 1
Last.Savarimuthu Ignacimuthu (University of Madras)H-Index: 46
view all 12 authors...
1 CitationsSource
#1Alexander Kokkinos (UoA: National and Kapodistrian University of Athens)H-Index: 15
#2Dimitrios Tsilingiris (UoA: National and Kapodistrian University of Athens)H-Index: 1
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 5 authors...
Source
#1Di Huang (Purdue University)
Last.Shihuan Kuang (Purdue University)H-Index: 31
view all 3 authors...
Source
#1Hsiao‐Huai Kuo (Mackay Memorial Hospital)
#2Kuang‐Te Wang (Mackay Memorial Hospital)
Last.Lawrence Yu‐Min Liu (Mackay Memorial Hospital)
view all 7 authors...
Source
Source
1 CitationsSource
#1Olivia M. Farr (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 20
#2Eleni Pilitsi (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 1
Last.Christos S. Mantzoros (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 106
view all 3 authors...
Source
Source