Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
Volume: 115, Issue: 46
Published: Oct 31, 2018
Abstract
Significance Here we demonstrate that Yersinia YopJ-induced murine macrophage death involves caspase-8–induced cleavage of both gasdermin D (GSDMD) and gasdermin E (GSDME). The ensuing cell death is rapid, morphologically is similar to pyroptosis, and induces IL-1 release. Recently, both GSDMD and GSDME were reported to be critical effectors of caspase-1/11–driven pyroptosis and caspase-3–dependent secondary necrosis, which prompted the...
Paper Details
Title
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection
Published Date
Oct 31, 2018
Volume
115
Issue
46
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