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Tackling the Concept of Symbiotic Implantable Medical Devices with Nanobiotechnologies

Published on Dec 1, 2018in Biotechnology Journal3.543
路 DOI :10.1002/biot.201800102
Jean-Pierre Alcaraz6
Estimated H-index: 6
,
Philippe Cinquin28
Estimated H-index: 28
,
Donald K. Martin20
Estimated H-index: 20
Abstract
  • References (116)
  • Citations (1)
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1 Author (Laurie Winkless)
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References116
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Abstract There is a growing interest in the design and engineering of operational biofuel cells that can be implanted. This review highlights the recent progress in the electrochemistry of biofuel cell technologies, but with a particular emphasis on the medical and physiological aspects that impact the biocompatibility of biofuel cells operating inside a living body. We discuss the challenge of supplying power to implantable medical devices, with regard to the limitations of lithium battery tech...
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Abstract Surface-induced thrombosis is still a significant clinical concern for many types of blood-contacting medical devices. In particular, protein adsorption and platelet adhesion are important events due to their ability to trigger the coagulation cascade and initiate thrombosis. Poly(lactic acid) (PLA) has been the predominant polymer used for making bioresorbable stents. Despite long-term advantages, these stents are associated with higher rates of early thrombosis compared with permanent...
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Abstract Objective Polysaccharide-based composite matrices consisting of natural polysaccharides, pullulan and dextran supplemented with hydroxyapatite (Matrix-HA) have recently been developed. The principal objective of this study was to evaluate the capacities of this composite material to promote new bone formation in a sinus lift model in the sheep. Secondary objectives were to evaluate in vitro properties of the material regarding cell adhesion and proliferation. Methods In this report, onc...
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Abstract A bioelectronic device comprising an enzymatic biofuel cell (GBFC) connected to a wireless tele-transmission system was implanted in a rabbit and its function was monitored and controlled in聽vivo for a period of 2 months. After the 18th day of implantation, the tele-transmission system was used to wirelessly charge and discharge the operational GBFC in聽vivo through a 100鈥痥惟 load for 30鈥痬in each day. For a further 16 days of operation, the GBFC delivered 16鈥糤鈥痬L鈭1 continuously during ea...
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