Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells
Abstract
Imaging chromatin spatial organization The genome is organized within the nucleus as three-dimensional domains that modulate DNA-templated processes. Bintu et al. used high-throughput Oligopaint labeling and imaging to observe chromatin dynamics inside the nuclei of several different mammalian cell lines. After combining the datasets, single-cell matrices revealed chromatin arranged in topologically associating domains (TADs). Removing cohesin...
Paper Details
Title
Super-resolution chromatin tracing reveals domains and cooperative interactions in single cells
Published Date
Oct 26, 2018
Journal
Volume
362
Issue
6413
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