Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation
Abstract
Pancreatic cancer remains one of the deadliest human cancers despite current advances in conventional therapeutics including surgery and adjuvant therapies. Here, we showed that LZ1, a peptide derived from a snake venom cathelicidin, significantly inhibited growth of pancreatic cancer cells by inducing autophagy-dependent cell death both in vitro and in vivo. The LZ1-induced cell death was blocked by pharmacological or genetic inhibition of...
Paper Details
Title
Targeting surface nucleolin induces autophagy-dependent cell death in pancreatic cancer via AMPK activation
Published Date
Oct 24, 2018
Journal
Volume
38
Issue
11
Pages
1832 - 1844
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History