Management of leptomeningeal metastases in EGFR mutated non-small cell lung cancer: Analysis of tyrosine kinase inhibitors sequence

Background: Non-small cell lung carcinomas (NSCLC) with leptomeningeal metastases are associated with poor outcomes. Tyrosine kinase inhibitors (TKI) in EGFR-mutated (EGFRm) tumors might have substantial activity. Impact of TKI sequence on survival and clinical benefit is unknown. Methods: Consecutive patients (pts) from 2 institutions with EGFRm NSCLC and LM were included. Retrospective collection of clinical, pathological and radiological data...