Hypertension and obesity moderate the relationship between β‐amyloid and cognitive decline in midlife

Background This study tested if central obesity, hypertension, or depressive symptoms moderated the relationship between β‐amyloid (Aβ) and longitudinal cognitive performance in late middle‐aged adults enriched for Alzheimer's disease (AD) risk. Methods Participants ( n = 207; ages = 40–70 years; 73% parental AD) in the Wisconsin Registry for Alzheimer's Prevention study completed 3+ neuropsychological evaluations and a [ 11 C]PiB positron...