Intra-CSF liposomal cytarabine plus systemic therapy as initial treatment of breast cancer leptomeningeal metastasis: A randomised, open-label trial

Background: The role of intra-cerebrospinal fluid (CSF) therapy for the treatment of leptomeningeal metastasis (LM) remains controversial. Methods: We conducted a multicenter randomized open-label study to explore the effect of the addition of liposomal cytarabine to systemic therapy for the treatment of LM from breast cancer. Inclusion was based on the detection of tumor cells in the CSF or typical clinical and magnetic resonance imaging (MRI)...