Circulating Metabolic Biomarkers of Screen-Detected Prostate Cancer in the ProtecT Study

Whether associations between circulating metabolites and prostate cancer are causal is unknown. We report on the largest study of metabolites and prostate cancer (2,291 cases and 2,661 controls) and appraise causality for a subset of the prostate cancer-metabolite associations using two-sample Mendelian randomization (MR).The case-control portion of the study was conducted in nine UK centers with men ages 50-69 years who underwent...