A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns
Abstract
Peritoneal invasion through the mesothelial cell layer is a hallmark of ovarian cancer metastasis. Using tissue engineering technologies, we recreated an ovarian tumor microenvironment replicating this aspect of disease progression. Ovarian cancer cell-laden hydrogels were combined with mesothelial cell-layered melt electrospun written scaffolds and characterized with proliferation and transcriptomic analyses and used as intraperitoneal...
Paper Details
Title
A 3D tumor microenvironment regulates cell proliferation, peritoneal growth and expression patterns
Published Date
Jan 1, 2019
Journal
Volume
190-191
Pages
63 - 75
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Notes
History