Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells
Abstract
Forkhead box transcription factor 3 (FOXP3) plays a pivotal role in the suppressive function of regulatory T cells. In addition to mRNA levels, FOXP3 activity can also be controlled by posttranslational mechanisms, which have not been studied in a comprehensive manner. Through extensive screening using selective inhibitors, we demonstrate that the inhibition of type I protein arginine methytransferases (PRMTs) attenuates the suppressive...
Paper Details
Title
Arginine methylation of FOXP3 is crucial for the suppressive function of regulatory T cells
Published Date
Feb 1, 2019
Journal
Volume
97
Pages
10 - 21
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