Review paper
mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus
Abstract
Type 2 Diabetes Mellitus (T2DM), a worldwide epidemics, is a progressive disease initially developing an insulin resistant, with a manifest pancreatic beta islets hyperplasia/hypertrophy and hyperinsulinemia. As the disease progresses, pancreatic β cells are overwhelmed and fails in their capacity to compensate insulin resistance. In addition, it is usually associated with other metabolic diseases such as hyperlipidemia, obesity and the...
Paper Details
Title
mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus
Published Date
Oct 16, 2018
Journal
Volume
9
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