mTORC1 Overactivation as a Key Aging Factor in the Progression to Type 2 Diabetes Mellitus

Type 2 Diabetes Mellitus (T2DM), a worldwide epidemics, is a progressive disease initially developing an insulin resistant, with a manifest pancreatic beta islets hyperplasia/hypertrophy and hyperinsulinemia. As the disease progresses, pancreatic β cells are overwhelmed and fails in their capacity to compensate insulin resistance. In addition, it is usually associated with other metabolic diseases such as hyperlipidemia, obesity and the...