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Relationship between patient presentation and morphology of coronary atherosclerosis by quantitative multidetector computed tomography

Published on Nov 1, 2019in European Journal of Echocardiography
· DOI :10.1093/ehjci/jey146
Martina Chantal de Knegt5
Estimated H-index: 5
(UCPH: University of Copenhagen),
Jesper J. Linde9
Estimated H-index: 9
(UCPH: University of Copenhagen)
+ 75 AuthorsSusette Krohn Therkelsen2
Estimated H-index: 2
Abstract
  • References (33)
  • Citations (2)
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References33
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#1Hyuk-Jae Chang (Yonsei University)H-Index: 40
#2Fay Y. Lin (NewYork–Presbyterian Hospital)H-Index: 41
Last. James K. Min (NewYork–Presbyterian Hospital)H-Index: 70
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Abstract Background The association of atherosclerotic features with first acute coronary syndromes (ACS) has not accounted for plaque burden. Objectives The purpose of this study was to identify atherosclerotic features associated with precursors of ACS. Methods We performed a nested case-control study within a cohort of 25,251 patients undergoing coronary computed tomographic angiography (CTA) with follow-up over 3.4 ± 2.1 years. Patients with ACS and nonevent patients with no prior coronary a...
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Well into the 21st century, we still triage acute myocardial infarction on the basis of the presence or absence of ST-segment elevation, a century-old technology. Meanwhile, we have learned a great deal about the pathophysiology and mechanisms of acute coronary syndromes (ACS) at the clinical, pathological, cellular, and molecular levels. Contemporary imaging studies have shed new light on the mechanisms of ACS. This review discusses these advances and their implications for clinical management ...
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#1Christian Tesche (MUSC: Medical University of South Carolina)H-Index: 11
#2Damiano Caruso (MUSC: Medical University of South Carolina)H-Index: 13
Last. U. Joseph Schoepf (MUSC: Medical University of South Carolina)H-Index: 55
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This study investigated the discriminatory value of quantitative atherosclerotic plaque markers derived from coronary computed tomography angiography (cCTA) in patients with first acute coronary syndrome (ACS) compared with patients with stable coronary artery disease (CAD). Forty patients (56.9 ± 9.3 years, 55% men) admitted with their first ACS and Framingham risk score–matched controls with stable CAD were retrospectively analyzed. All patients had undergone cCTA followed by invasive coronary...
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#1J. Tobias Kühl (UCPH: University of Copenhagen)H-Index: 8
#2Jens D. Hove (UCPH: University of Copenhagen)H-Index: 13
Last. Klaus F. Kofoed (UCPH: University of Copenhagen)H-Index: 30
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AbstractObjectives. To test if cardiac computed tomography angiography (CCTA) can be used in the triage of patients at high risk of coronary artery disease. Design. The diagnostic value of 64-detector CCTA was evaluated in 400 patients presenting with non-ST segment elevation myocardial infarction using invasive coronary angiography (ICA) as the reference method. The relation between the severity of disease by CCTA and a combined endpoint of death, re-hospitalization due to new myocardial infarc...
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#1Chuan ZhouH-Index: 26
#2Heang Ping ChanH-Index: 56
Last. Ella A. KazerooniH-Index: 68
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#1Alexander Broersen (LUMC: Leiden University Medical Center)H-Index: 15
#2Michiel A. de Graaf (LUMC: Leiden University Medical Center)H-Index: 11
Last. Arthur J.H.A. Scholte (LUMC: Leiden University Medical Center)H-Index: 24
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We enhance intravascular ultrasound virtual histology (VH) tissue characterization by fully automatic quantification of the acoustic shadow behind calcified plaque. VH is unable to characterize atherosclerosis located behind calcifications. In this study, the quantified acoustic shadows are considered calcified to approximate the real dense calcium (DC) plaque volume. In total, 57 patients with 108 coronary lesions were included. A novel post-processing step is applied on the VH images to quanti...
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#2Joerg Hausleiter (LMU: Ludwig Maximilian University of Munich)H-Index: 56
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Abstract Objective We sought to assess the incremental prognostic value of quantitative plaque characterization beyond established CT risk scores. Background Several plaque characteristics detectable by coronary computed tomographic angiography (coronary CTA) are thought to be indicative of vulnerable plaques and subsequent cardiac events, particularly low attenuation plaque volume (LAPV), positive remodeling and the napkin-ring sign which is high density vascular adhesion with a small center of...
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#1Armin Arbab-Zadeh (Johns Hopkins University)H-Index: 36
#2Valentin Fuster MDPhD (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 167
Abstract The cardiovascular science community has pursued the quest to identify vulnerable atherosclerotic plaque in patients for decades, hoping to prevent acute coronary events. However, despite major advancements in imaging technology that allow visualization of rupture-prone plaques, clinical studies have not demonstrated improved risk prediction compared with traditional approaches. Considering the complex relationship between plaque rupture and acute coronary event risk suggested by pathol...
178 CitationsSource
#1Farhood Saremi (SC: University of Southern California)H-Index: 22
#2Stephan AchenbachH-Index: 93
OBJECTIVE. In this article, we review the histopathologic classification of coronary atherosclerotic plaques and describe the possibilities and limitations of CT regarding the evaluation of coronary artery plaques. CONCLUSION. The composition of atherosclerotic plaques in the coronary arteries displays substantial variability and is associated with the likelihood for rupture and downstream ischemic events. Accurate identification and quantification of coronary plaque components on CT is challeng...
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#1Michael Y. Henein (Brunel University London)
Last. Federico VancheriH-Index: 1
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Identifying patients at increased risk of coronary artery disease, before the atherosclerotic complications become clinically evident, is the aim of cardiovascular prevention. Imaging techniques provide direct assessment of coronary atherosclerotic burden and pathological characteristics of atherosclerotic lesions which may predict the progression of disease. Atherosclerosis imaging has been traditionally based on the evaluation of coronary luminal narrowing and stenosis. However, the degree of ...
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#1Alexander R. van Rosendael (NewYork–Presbyterian Hospital)H-Index: 6
#2Jeroen J. Bax (NewYork–Presbyterian Hospital)H-Index: 1
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