Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
Abstract
In cancer cells, loss of G1/S control is often accompanied by p53 pathway inactivation, the latter usually rationalized as a necessity for suppressing cell cycle arrest and apoptosis. However, we found an unanticipated effect of p53 loss in mouse and human G1-checkpoint-deficient cells: reduction of DNA damage. We show that abrogation of the G1/S-checkpoint allowed cells to enter S-phase under growth-restricting conditions at the expense of...
Paper Details
Title
Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
Published Date
Oct 16, 2018
Journal
Volume
7
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