Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology

Volume: 140, Issue: 44, Pages: 15114 - 15123
Published: Oct 17, 2018
Abstract
Chemical biology research often requires precise covalent attachment of labels to the native proteins. Such methods are sought after to probe, design, and regulate the properties of proteins. At present, this demand is largely unmet due to the lack of empowering chemical technology. Here, we report a chemical platform that enables site-selective labeling of native proteins. Initially, a reversible intermolecular reaction places the “chemical...
Paper Details
Title
Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology
Published Date
Oct 17, 2018
Volume
140
Issue
44
Pages
15114 - 15123
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