Early Introduction of cART Reverses Brain Aging Pattern in Well-Controlled HIV Infection: A Comparative MR Spectroscopy Study

Introduction: The aim of this study was to compare age-related changes in chronically-infected, asymptomatic HIV-positive patients under combination antiretroviral therapy (cART), with age-, gender- and educational-level-matched healthy subjects, using multi-voxel magnetic resonance spectroscopy (MRS). Methods: There were 66 chronically infected HIV+ subjects and 65 age-, gender- and educational-level-matched control subjects, divided into four...