Mosaicism in CRISPR/Cas9-mediated genome editing
Abstract
The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing method. This method has been used in a variety of organisms and cell types over the past several years. However, using this technology for generating gene-edited animals involves a number of obstacles. One such obstacle is mosaicism, which is common in founder animals. This is especially the case when the CRISPR/Cas9 system is used in embryos. Here we review...
Paper Details
Title
Mosaicism in CRISPR/Cas9-mediated genome editing
Published Date
Jan 1, 2019
Journal
Volume
445
Issue
2
Pages
156 - 162
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