Identification of Novel Scaffolds with Dual Role as Antiepileptic and Anti-Breast Cancer

Aromatase inhibitors with an \mathrm{IC}_{50}IC 50 value ranging from 1.4 to 49.7 µM are known to act as antiepileptic drugs besides being potential breast cancer inhibitors. The aim of the present study is to identify novel antiepileptic aromatase inhibitors with higher activity exploiting the ligand-based pharmacophore approach utilizing the experimentally known inhibitors. The resultant Hypo1 consists of four features and was further...