Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade
Abstract
The thioredoxin (Trx)-coupled arsenate reductase (ArsC) is a family of enzymes that catalyzes the reduction of arsenate to arsenite in the arsenic detoxification pathway. The catalytic cycle involves a series of relayed intramolecular and intermolecular thiol-disulfide exchange reactions. Structures at different reaction stages have been determined, suggesting significant conformational fluctuations along the reaction pathway. Herein, we use two...
Paper Details
Title
Intra- and inter-protein couplings of backbone motions underlie protein thiol-disulfide exchange cascade
Published Date
Oct 18, 2018
Journal
Volume
8
Issue
1
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