Plasma tryptase elevation during aspirin-induced reactions in aspirin-exacerbated respiratory disease

Mast cell activation in the respiratory tract is a well-recognized feature of aspirin-induced respiratory reactions in patients with aspirin-exacerbated respiratory disease (AERD). This activation is reflected by release of tryptase and production of lipid mediators, which can result in substantial bronchoconstriction. The use of drugs that target cysteinyl leukotriene (cysLT) synthesis or that block the type 1 cysLT receptor (CysLT1R) can...