Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee

Published on Dec 1, 2018in Current Reviews in Musculoskeletal Medicine
· DOI :10.1007/s12178-018-9524-x
Corey S. Cook1
Estimated H-index: 1
Patrick A. Smith12
Estimated H-index: 12
(MU: University of Missouri)
Purpose of Review The purpose of this review is to update the reader on the current applications of platelet-rich plasma (PRP) in the treatment of knee osteoarthritis (KOA). This review will focus on PRP’s effect on the osteoarthritic joint, how PRP compares to traditional treatments of KOA, and provide clinical feedback on the use of PRP in an orthopedic and sports medicine practice.
  • References (120)
  • Citations (3)
📖 Papers frequently viewed together
1 Citations
35 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
#1Lucy C. Walker (Freeman Hospital)H-Index: 2
#2Nicholas D. Clement (Freeman Hospital)H-Index: 15
Last. David J. Deehan (Freeman Hospital)H-Index: 35
view all 3 authors...
It is estimated that up to a third of recipients of total knee arthroplasty (TKA) experience chronic pain postoperatively. However, there are no clear indications within the literature that predict which patients are at higher risk of being dissatisfied with their TKA. The Western Ontario and McMaster University Osteoarthritis Index (WOMAC) is one of the most commonly used, patient-reported outcome measures in patients with lower limb osteoarthritis. This review discusses the available evidence ...
1 CitationsSource
#1Alessio BriccaH-Index: 3
#2Carsten Bogh JuhlH-Index: 17
Last. Ewa M. RoosH-Index: 65
view all 5 authors...
Objective To investigate the impact of knee joint loading exercise on articular cartilage in people at risk of, or with established, knee osteoarthritis (OA) by conducting a systematic review of randomised controlled trials (RCTs). Design We followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. Data sources We performed a literature search with no restriction on publication year or language in MEDLINE, EMBASE, CINAHL, the Cochrane Central Register of Control...
13 CitationsSource
#1Asimina Lazaridou (Brigham and Women's Hospital)H-Index: 8
#2Marc O. Martel (Brigham and Women's Hospital)H-Index: 16
Last. Robert R. Edwards (Brigham and Women's Hospital)H-Index: 66
view all 9 authors...
3 CitationsSource
#2Mohit BhandariH-Index: 82
Last. Moin KhanH-Index: 13
view all 7 authors...
Background:Guidelines recommending various nonoperative treatments for patients with knee osteoarthritis remain inconsistent. Much of this controversy relates to what constitutes a clinically important effect. The purposes of the present study were to compare treatment effect sizes from recent meta-
12 CitationsSource
Background:Preliminary research suggests that bone marrow concentrate (BMC), which contains mesenchymal stem cells and platelets, is a promising treatment for knee osteoarthritis. The aim of this study was to build on this preliminary research by reporting the short-term progress of 15 patients (20 knees) with knee osteoarthritis through 4 BMC treatments.Methods:Patients underwent four sequential BMC treatments with mean injection times of 13.80 days after the first treatment, 21.40 days after t...
6 CitationsSource
#1David M. Levy (Rush University Medical Center)H-Index: 10
#2Kyle A. Petersen (Rush University Medical Center)H-Index: 1
Last. Brian J. Cole (Rush University Medical Center)H-Index: 95
view all 5 authors...
Abstract This article reviews the benefits of corticosteroid, viscosupplementation, platelet-rich plasma, and autologous mesenchymal stem cell injections for the treatment of patients with knee osteoarthritis. Integrating injections into both clinical and surgical practices is complicated given existing health insurance reimbursement policies. This review describes the outcomes associated with these interventions and appropriate methods of navigating the existing reimbursement pathways to help p...
8 CitationsSource
#1Lei ZhaoH-Index: 5
#2Alan D. KayeH-Index: 32
Last. Alaa Abd-ElsayedH-Index: 5
view all 3 authors...
2 Citations
#1Hamada S Ahmad (Mansoura University)H-Index: 3
#2Sherief E Farrag (Mansoura University)H-Index: 1
Last. Ibrahim Shady (Mansoura University)H-Index: 1
view all 7 authors...
6 CitationsSource
Abstract Biological-based therapies for cartilage pathology have gained considerable recognition in the last few decades due to their potential benefits including their minimal invasiveness, capacity for unprecedented healing, and potential for rapid recovery. Consequently, these therapies are likely to have the most noteworthy impact on patients with degenerative joint changes who want to remain active. Currently, the most researched treatments include platelet-rich plasma (PRP), bone marrow as...
5 CitationsSource
#1Tom Arild Torstensen (KI: Karolinska Institutet)H-Index: 7
Last. Björn O. ÄngH-Index: 12
view all 6 authors...
INTRODUCTION: Osteoarthritis (OA) of the knee is characterised by knee pain, disability and degenerative changes, and places a burden on societies all over the world. Exercise therapy is an often-u ...
3 CitationsSource
Cited By3
#1John Apostolakos (HSS: Hospital for Special Surgery)H-Index: 14
#2Kenneth M. Lin (HSS: Hospital for Special Surgery)H-Index: 2
Last. Joshua S. Dines (HSS: Hospital for Special Surgery)H-Index: 36
view all 6 authors...
PURPOSE OF REVIEW: Injuries to the elbow ulnar collateral ligament (UCL) are especially common in the overhead throwing athlete. Despite preventative measures, these injuries are occurring at increasing rates in athletes of all levels. UCL reconstruction techniques generally require a prolonged recovery period and introduce the potential for intraoperative complications prompting investigations into more conservative treatment measures based on specific patient and injury characteristics. The pu...
#2Panpicha Sattasathuchana (Kasetsart University)H-Index: 5
Last. Naris Thengchaisri (Kasetsart University)H-Index: 8
view all 4 authors...
BACKGROUND: Carprofen and platelet-rich plasma (PRP) are widely used in small animal clinical practice. Separation layers have been used during blood centrifugation to increase platelet yield. The objectives of this study were to (1) identify the optimal centrifugation force for the one-step PRP preparation, (2) determine whether there is an advantage to using carprofen in one-step PRP preparation, and (3) compare platelet morphology from one-step PRP preparation with and without carprofen. We h...
#1Masahiko Kenmochi (Kyorin University)
#1Masahiko Kemmochi (Kyorin University)H-Index: 1
Abstract Background Scientists are trying to discover how to repair cartilage defects in knee osteoarthritis (KOA). In our previous study, we found a fibrocartilage-rich cover over the defective portions of cartilage after administering leukocyte-rich platelet-rich plasma (LR-PRP). This study aimed to investigate the efficacy of multiple injections of LR-PRP for the treatment of KOA and determine an LR-PRP treatment protocol for KOA in actual clinical practice. Hypothesis We hypothesized that us...
#2Kyle Fisher (Duke University)
Last. Richard L. Boortz-Marx (Duke University)H-Index: 9
view all 4 authors...
Knee osteoarthritis is a common painful degenerative condition affecting the aging Canadian population. In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. It is predicted to cost the Canadian healthcare system $7.6 billion dollars by 2031. Despite its high cost and prevalence, controversy persists in the medical community regarding optimal therapies to treat knee osteoarthritis. A variety of medi...
#1Erik Hohmann (University of Pretoria)H-Index: 15
#2Kevin TetsworthH-Index: 20
Last. Vaida Glatt (University of Texas Health Science Center at San Antonio)H-Index: 20
view all 3 authors...
Introduction The purpose of this study was to perform a systematic review and meta-analysis comparing intra-articular knee injection of PRP and hyaluronic acid and investigate clinical outcomes and pain at both 6 and 12 months.
1 CitationsSource
#1Brian C. Werner (University of Virginia Health System)H-Index: 23
Last. Brian J. ColeH-Index: 95
view all 5 authors...
Background:The use of platelet-rich plasma (PRP) in the Medicare population is not well described.Purpose:To investigate the national use of PRP among Medicare beneficiaries, including the incidenc...
#1Gloria María Pontes-Quero (CSIC: Spanish National Research Council)H-Index: 1
#2Luis García-Fernández (CSIC: Spanish National Research Council)H-Index: 19
Last. Blanca Vázquez-Lasa (CSIC: Spanish National Research Council)H-Index: 5
view all 6 authors...
Abstract Objective Osteoarthritis is a chronic, painful and disabling disease which prevalence is increasing in developing countries. Patients with osteoarthritis present a reduced synovial fluid viscoelasticity due to a reduction in concentration and molecular weight of hyaluronic acid. Currently, the main treatment used to restore the compromised rheological properties of synovial fluid is the viscosupplementation by hyaluronic acid injections that can be combined with oral anti-inflammatory d...
1 CitationsSource
#1Ibrahim Fatih Cengiz (University of Minho)H-Index: 6
#2Hélder Pereira (University of Minho)H-Index: 11
Last. Joaquim M. Oliveira (University of Minho)H-Index: 32
view all 5 authors...
Purpose of Review Overview the outcomes of the latest use of platelet-rich plasma (PRP) for the treatment of knee lesions in the clinics and discuss the challenges and limitations.
#1Michael Baria (The Ohio State University Wexner Medical Center)H-Index: 1
#2W. Kelton Vasileff (The Ohio State University Wexner Medical Center)H-Index: 1
Last. Sushmitha S. Durgam (The Ohio State University Wexner Medical Center)
view all 6 authors...
Background:Platelet-rich plasma (PRP) is an autologous orthobiologic treatment option for musculoskeletal conditions with favorable results in a limited number of high-quality clinical trials. Beca...