F1‐03‐01: CONVECTIVE INFLUX/GLYMPHATIC SYSTEM: TRACERS INJECTED INTO THE CSF ENTER AND LEAVE THE BRAIN ALONG SEPARATE PERIARTERIAL BASEMENT MEMBRANE PATHWAYS

Accumulation of the β-amyloid (Aβ) protein in blood vessels is a hallmark of Alzheimer's disease. Soluble Aβ is removed along the intramural periarterial drainage (IPAD) pathways consisting of basement membranes of capillaries and arteries towards the leptomeningeal compartment. Aβ is present in the cerebrospinal fluid (CSF) of the brain and the glymphatic hypothesis suggests that Aβ is entering the parenchyma and eliminated back into the CSF....