Neural blastocyst complementation enables mouse forebrain organogenesis
Abstract
Genetically modified mice are commonly generated by the microinjection of pluripotent embryonic stem (ES) cells into wild-type host blastocysts1, producing chimeric progeny that require breeding for germline transmission and homozygosity of modified alleles. As an alternative approach and to facilitate studies of the immune system, we previously developed RAG2-deficient blastocyst complementation2. Because RAG2-deficient mice cannot undergo...
Paper Details
Title
Neural blastocyst complementation enables mouse forebrain organogenesis
Published Date
Oct 10, 2018
Journal
Volume
563
Issue
7729
Pages
126 - 130
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