Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
Abstract
Salmeterol is a partial agonist for the β2 adrenergic receptor (β2AR) and the first long-acting β2AR agonist to be widely used clinically for the treatment of asthma and chronic obstructive pulmonary disease. Salmeterol’s safety and mechanism of action have both been controversial. To understand its unusual pharmacological action and partial agonism, we obtained the crystal structure of salmeterol-bound β2AR in complex with an...
Paper Details
Title
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist
Published Date
Oct 16, 2018
Journal
Volume
14
Issue
11
Pages
1059 - 1066
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