Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing
Abstract
Metformin is the first-choice therapy to lower glycaemia and manage type 2 diabetes. Continuously emerging epidemiological data and experimental models are showing additional protective effects of metformin against a number of age-related diseases (ARDs), e.g., cardiovascular diseases and cancer. This evidence has prompted the design of a specific trial, i.e., the Targeting Aging with Metformin (TAME) trial, to test metformin as an anti-ageing...
Paper Details
Title
Pleiotropic effects of metformin: Shaping the microbiome to manage type 2 diabetes and postpone ageing
Published Date
Dec 1, 2018
Journal
Volume
48
Pages
87 - 98
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