Match!

Herpesvirus trigger accelerates neuroinflammation in a nonhuman primate model of multiple sclerosis

Published on Oct 30, 2018in Proceedings of the National Academy of Sciences of the United States of America9.58
· DOI :10.1073/pnas.1811974115
Emily C. Leibovitch10
Estimated H-index: 10
(NIH: National Institutes of Health),
Breanna Caruso6
Estimated H-index: 6
(NIH: National Institutes of Health)
+ 10 AuthorsSteven Jacobson55
Estimated H-index: 55
(NIH: National Institutes of Health)
Abstract
Pathogens, particularly human herpesviruses (HHVs), are implicated as triggers of disease onset/progression in multiple sclerosis (MS) and other neuroinflammatory disorders. However, the time between viral acquisition in childhood and disease onset in adulthood complicates the study of this association. Using nonhuman primates, we demonstrate that intranasal inoculations with HHV-6A and HHV-6B accelerate an MS-like neuroinflammatory disease, experimental autoimmune encephalomyelitis (EAE). Although animals inoculated intranasally with HHV-6 (virus/EAE marmosets) were asymptomatic, they exhibited significantly accelerated clinical EAE compared with control animals. Expansion of a proinflammatory CD8 subset correlated with post-EAE survival in virus/EAE marmosets, suggesting that a peripheral (viral?) antigen-driven expansion may have occurred post-EAE induction. HHV-6 viral antigen in virus/EAE marmosets was markedly elevated and concentrated in brain lesions, similar to previously reported localizations of HHV-6 in MS brain lesions. Collectively, we demonstrate that asymptomatic intranasal viral acquisition accelerates subsequent neuroinflammation in a nonhuman primate model of MS.
  • References (44)
  • Citations (8)
References44
Newest
#1Nathanael J. Lee (NIH: National Institutes of Health)H-Index: 2
#2Seung-Kwon Ha (NIH: National Institutes of Health)H-Index: 3
Last.Daniel S. Reich (NIH: National Institutes of Health)H-Index: 48
view all 14 authors...
13 CitationsSource
#1Daniel Papoti (NIH: National Institutes of Health)H-Index: 5
#2Cecil Chern-Chyi Yen (NIH: National Institutes of Health)H-Index: 11
Last.Afonso C. Silva (NIH: National Institutes of Health)H-Index: 35
view all 6 authors...
7 CitationsSource
10 CitationsSource
#1Cheng-Te Major Lin (GW: George Washington University)H-Index: 2
#2Emily C. Leibovitch (GW: George Washington University)H-Index: 10
Last.Steven Jacobson (NIH: National Institutes of Health)H-Index: 55
view all 4 authors...
10 CitationsSource
#1Elisabeth B. Lucassen (Penn State Milton S. Hershey Medical Center)H-Index: 6
#2Anthony P. Turel (Penn State Milton S. Hershey Medical Center)H-Index: 5
Last.Paul J. Eslinger (Penn State Milton S. Hershey Medical Center)H-Index: 49
view all 5 authors...
14 CitationsSource
#1Costanza CasiraghiH-Index: 3
Last.Marc S. HorwitzH-Index: 16
view all 4 authors...
13 CitationsSource
#1Emily C. Leibovitch (GW: George Washington University)H-Index: 10
#2Steven Jacobson (NIH: National Institutes of Health)H-Index: 55
48 CitationsSource
#1Pietro Maggi (UniFI: University of Florence)H-Index: 7
#2Sheila Cummings Sm Macri (Harvard University)H-Index: 6
Last.Daniel S. Reich (NIH: National Institutes of Health)H-Index: 48
view all 13 authors...
47 CitationsSource
#1Dharam V. AblashiH-Index: 47
#2Henri AgutH-Index: 43
Last.Tetsushi Yoshikawa (Fujita Health University)H-Index: 41
view all 21 authors...
138 CitationsSource
#1Emily C. Leibovitch (GW: George Washington University)H-Index: 10
#2Giovanna S Brunetto (NIH: National Institutes of Health)H-Index: 3
Last.Steven Jacobson (NIH: National Institutes of Health)H-Index: 55
view all 7 authors...
29 CitationsSource
Cited By8
Newest
#1Praveen Bathini (University of Fribourg)H-Index: 1
#2Emanuele Brai (Katholieke Universiteit Leuven)
Last.Lavinia Alberi Auber (University of Fribourg)H-Index: 1
view all 3 authors...
Source
1 CitationsSource
Source
#1Rosella Mechelli (OU: Open University)H-Index: 1
#2Renato Umeton (Harvard University)H-Index: 10
Last.Giovanni Ristori (Sapienza University of Rome)H-Index: 26
view all 9 authors...
Source
#1Luisa F. Duarte (UC: Pontifical Catholic University of Chile)H-Index: 1
#2Mónica A. Farías (UC: Pontifical Catholic University of Chile)H-Index: 2
Last.Pablo A. González (UC: Pontifical Catholic University of Chile)H-Index: 22
view all 6 authors...
1 CitationsSource
#1Carla T. Toro (Warw.: University of Warwick)H-Index: 1
#2Eva EliassenH-Index: 3
Last.Bhupesh K. Prusty (University of Würzburg)H-Index: 15
view all 3 authors...
Source
#1Hamid Zahednasab (UT: University of Tehran)H-Index: 6
#2Hossein Keyvani (IUMS: Iran University of Medical Sciences)H-Index: 17
Last.Mohammad Hossein Harirchian (Tehran University of Medical Sciences)H-Index: 13
view all 4 authors...
2 CitationsSource
#1Emily C. Leibovitch (NIH: National Institutes of Health)H-Index: 10
#2Steven Jacobson (NIH: National Institutes of Health)H-Index: 55
Source