P2‐105: NOMINATION OF NOVEL CANDIDATE GENES FOR FAMILIAL LATE ONSET ALZHEIMER DISEASE AFTER EVALUATION OF GENE‐BASED FAMILY‐BASED METHODS

Gene-based analysis are the reference approach to study the effect of rare variants in a particular phenotype. There are a plethora of software and tests for case-control studies. However, their evolution and adaptation for family-based studies, especially for complex incomplete families, has been slower. We have performed a practical examination of most recent and most widely used gene-based methods available for family-based study. We have...