A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas
Abstract
Schwannomas are common, highly morbid and medically untreatable tumors that can arise in patients with germ line as well as somatic mutations in neurofibromatosis type 2 (NF2). These mutations most commonly result in the loss of function of the NF2-encoded protein, Merlin. Little is known about how Merlin functions endogenously as a tumor suppressor and how its loss leads to oncogenic transformation in Schwann cells (SCs). Here, we identify...
Paper Details
Title
A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas
Published Date
Oct 17, 2018
Journal
Volume
28
Issue
4
Pages
572 - 583
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