Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5′flanking region
Abstract
Vanadate, a protein tyrosine phosphatase inhibitor which elicits insulin-like effects, has previously been shown to inhibit expression of the insulin receptor gene at the transcriptional level in rat hepatoma cells. In an attempt to identify the DNA sequence and transcription factors potentially involved in this effect, a fragment of the proximal 5'flanking region of the IR gene (-1143/-252 upstream the ATG codon) has been cloned and...
Paper Details
Title
Vanadate inhibits transcription of the rat insulin receptor gene via a proximal sequence of the 5′flanking region
Published Date
Dec 1, 2018
Journal
Volume
7
Pages
26 - 32
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