Identifying loci affecting trait variability and detecting interactions in genome-wide association studies
Abstract
Identification of genetic variants with effects on trait variability can provide insights into the biological mechanisms that control variation and can identify potential interactions. We propose a two-degree-of-freedom test for jointly testing mean and variance effects to identify such variants. We implement the test in a linear mixed model, for which we provide an efficient algorithm and software. To focus on biologically interesting settings,...
Paper Details
Title
Identifying loci affecting trait variability and detecting interactions in genome-wide association studies
Published Date
Oct 15, 2018
Journal
Volume
50
Issue
11
Pages
1608 - 1614
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