Commentary: Timing for aortic surgery in rare genetic variants: When prevention warrants intervention?

Central MessageTiming for surgery is a major conundrum in the presence of rare variants of gene mutations.See Article page e107. Timing for surgery is a major conundrum in the presence of rare variants of gene mutations. See Article page e107. Although clinical guidance for surgical intervention in patients with common syndromic forms of aortic disease (eg, Marfan, Ehlers–Danlos, and Loeys–Dietz) is well established, the indications in less...