Publisher Correction: Base editing: precision chemistry on the genome and transcriptome of living cells

Published on Dec 1, 2018in Nature Reviews Genetics43.704
· DOI :10.1038/s41576-018-0068-0
Holly A. Rees10
Estimated H-index: 10
(Broad Institute),
David R. Liu73
Estimated H-index: 73
(Broad Institute)
The originally published article contained errors in reference numbering throughout table 1 (DNA base editors and their approximate editing windows) due to the unintended propagation of reference numbering from an earlier version of the table. The article has now been corrected online. The editors apologize for this error.
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Base editors hold promise for correcting pathogenic mutations, while substantial single nucleotide variations (SNVs) on both DNA and RNA were generated by cytosine base editors (CBEs). Here we examined possibilities to reduce off-target effects by engineering cytosine deaminases. By screening 24 CBEs harboring various rAPOBEC1 (BE3) or human APOBEC3A (BE3-hA3A) mutations on the ssDNA or RNA binding domain, we found 8 CBE variations could maintain high on-target editing efficiency. Using Genome-w...
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