Change in FEV1 and Feno Measurements as Predictors of Future Asthma Outcomes in Children

Background Repeated measurements of spirometry and fractional exhaled nitric oxide (Feno) are recommended as part of the management of childhood asthma, but the evidence base for such recommendations is small. We tested the hypothesis that reducing spirometric indices or increasing Feno will predict poor future asthma outcomes. Methods A one-stage individual patient data meta-analysis used data from seven randomized controlled trials in which...