P2‐262: A CEREBROSPINAL FLUID PANEL OF SYNAPTIC PROTEINS ACROSS THE ENTIRE ALZHEIMER'S DISEASE CONTINUUM

Alzheimer's disease (AD) is characterised by early and profound synapse loss. Consequently, an in vivo marker of synapse degeneration would be an excellent addition to the AD biomarker arsenal. The synaptic component of the cerebrospinal fluid (CSF) was characterised by combining high-throughput discovery proteomics with an exhaustive search of the literature and public databases. Evaluation of synapse-specific expression of the panel proteins...