P1‐092: NEUROPROTECTIVE EFFECTS OF PKR KNOCKOUT IN 5XFAD ALZHEIMER MICE AND NEURON‐MICROGLIA CO‐CULTURES
Abstract
Alzheimer's disease (AD) brain lesions associate amyloid plaques made of Aβ peptide and neurofibrillary tangles formed by hyperphophorylated tau protein with synaptic and neuronal losses as well as neuroinflammation. Aβ oligomers are hypothesized to trigger tau phosphorylation and neuronal alterations through activation of neuronal kinases leading to progressive cognitive decline. PKR is a ubiquitous pro-apoptotic serine/threonine kinase and...
Paper Details
Title
P1‐092: NEUROPROTECTIVE EFFECTS OF PKR KNOCKOUT IN 5XFAD ALZHEIMER MICE AND NEURON‐MICROGLIA CO‐CULTURES
Published Date
Jul 1, 2018
Journal
Volume
14
Issue
7S_Part_5
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