Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance
Abstract
The methylation of arginine residues in proteins is a post-translational modification that contributes to a wide range of biological processes. Many cytokines involved in T cell development and activation utilize the common cytokine receptor γ-chain (γc) and the kinase JAK3 for signal transduction, but the regulatory mechanism that underlies the expression of these factors remains unclear. Here we found that the arginine methyltransferase PRMT5...
Paper Details
Title
Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance
Published Date
Oct 15, 2018
Journal
Volume
19
Issue
11
Pages
1265 - 1276
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