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Non-polar lipid carbonyls of thermally oxidized coconut oil induce hepatotoxicity mediated by redox imbalance

Published on Nov 1, 2018in Prostaglandins Leukotrienes and Essential Fatty Acids2.86
· DOI :10.1016/j.plefa.2018.10.004
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Anu Anil1
Estimated H-index: 1
(University of Calicut)
+ 2 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
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Abstract
Abstract Thermal oxidation products of edible oils including aldehydes, peroxides and polymerized triglycerides formed during the cooking process are increasingly debated as contributory to chronic degenerative diseases. Depending on the oil used for cooking, the source of fatty acids and its oxidation products may vary and would have a differential influence on the physiological process. Coconut oil (CO) is a medium chain triglyceride-rich edible oil used in South India and other Asia Pacific countries for cooking purposes. The present study evaluated the biological effects of thermally oxidized coconut oil (TCO) as well as its non- polar hexane (TCO H) and polar methanol (TCO-M) sub-fractions in male Wistar rats. Results showed an increase in the thiobarbituric acid reactive substances (TBARs) and conjugated diene levels in TCO, which was extracted to TCO H fraction. The animals consumed TCO and its hexane and methanol fractions had a considerable increase in weight gain. However, serum and hepatic triglycerides were increased only in animals with TCO and TCO H administration. In these animals, the hepatic redox balance was disturbed, with a reduction in GSH and a concomitant increase in thiobarbituric acid reactive substances (TBARs). Increased incidence of microvesicles in hepatic histological observations also supported this assumption. Together, the study shows that TCO consumption is unhealthy, where the nonpolar compounds generated during thermal oxidation may be involved in the toxic insults.
  • References (43)
  • Citations (1)
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References43
Newest
Published on Jul 11, 2018in Journal of Agricultural and Food Chemistry3.57
Jean Mboma1
Estimated H-index: 1
,
Nadine Leblanc4
Estimated H-index: 4
(Laval University)
+ 8 AuthorsThierry Durand32
Estimated H-index: 32
(University of Montpellier)
This study assesses the effects of cyclic fatty acid monomers (CFAM) from heated vegetable oils on oxidative stress and inflammation. Wistar rats were fed either of these four diets for 28 days: canola oil (CO), canola oil and 0.5% CFAM (CC), soybean oil (SO), and soybean oil and 0.5% CFAM (SC). Markers of oxidative stress and inflammation were determined by micro liquid chromatography tandem mass spectrometry (micro-LC–MS/MS) and enzyme-linked immunosorbent assay (ELISA) kits, respectively. Ana...
Published on Mar 1, 2018in Journal of the Science of Food and Agriculture2.42
Arunaksharan Narayanankutty6
Estimated H-index: 6
,
Devika Mukundan Palliyil1
Estimated H-index: 1
+ 1 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
Hepatosteatosis, a form of nonalcoholic fatty liver disease (NAFLD), is being increasingly recognized as a major health burden worldwide. Insulin resistance, dyslipidemia and imbalances in adipokine/cytokine interplay are reported to be involved in the onset and progression of this disease. Use of dietary nutraceuticals in prevention and treatment of NAFLD is emerging. Virgin coconut oil (VCO), a fermented product of fresh coconut kernel, has been shown to impede the development of hepatosteatos...
Published on Sep 1, 2017in Human & Experimental Toxicology2.17
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Jj Manalil4
Estimated H-index: 4
(University of Calicut)
+ 6 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Hepatosteatosis is a complex disorder, in which insulin resistance and associated dyslipidemic and inflammatory conditions are fundamental. Dietary habit, especially regular consumption of fat and sugar-rich diet, is an important risk factor. Coconut and mustard oils (CO and MO) are medium-chain saturated and monounsaturated fats that are common dietary ingredients among the Indian populations. Present study analyzed the effect of prolonged consumption of the fresh and thermally oxidized forms o...
Published on Jul 24, 2017in Toxicology Mechanisms and Methods2.28
Soorya Parathodi Illam4
Estimated H-index: 4
,
Arunaksharan Narayanankutty6
Estimated H-index: 6
,
Achuthan C. Raghavamenon5
Estimated H-index: 5
AbstractVirgin coconut oil (VCO), extracted from the fresh coconut kernel, is a food supplement enriched with medium chain saturated fatty acids and polyphenolic antioxidants. It is reported to have several health benefits including lipid lowering, antioxidant and anti-inflammatory activities. The pharmacological benefits of VCO have been attributed to its polyphenol content (VCOP), the mechanistic basis of which is less explored. Liquid chromatography/mass spectroscopy (LC/MS) analysis of VCOP ...
Published on Mar 24, 2017in Toxicology Mechanisms and Methods2.28
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Anagha Kottekkat1
Estimated H-index: 1
(University of Calicut)
+ 3 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
AbstractOmega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in ...
Published on Jan 11, 2017in Journal of Agricultural and Food Chemistry3.57
Xiaodan Li4
Estimated H-index: 4
,
Xiaoyan Yu1
Estimated H-index: 1
+ 4 AuthorsYuanfa Liu16
Estimated H-index: 16
In the present study, effects of deep-fried palm oil, specifically polar compounds generated during the frying process, on animal health including lipid and glucose metabolism and liver functions were investigated. Kunming mice were fed a high-fat diet containing deep-fried palm oil or purified polar compounds for 12 weeks. Their effects on animal health including hepatic lipid profile, antioxidant enzyme activity, serum biochemistry, and glucose tolerance were analyzed. Our results revealed tha...
Published on Dec 1, 2016in Plant Foods for Human Nutrition2.60
Devi Lekshmi Sheela1
Estimated H-index: 1
(Kerala Agricultural University),
Puthiyaveetil Abdulla Nazeem1
Estimated H-index: 1
(Kerala Agricultural University)
+ 2 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
The coconut oil (CO) contains 91 % of saturated fatty acids in which 72 % are medium chain fatty acids (MCFAs) like lauric, capric and caprylic acids. In contrast to animal fat, coconut oil has no cholesterol. Despite this fact, CO is sidelined among other vegetable oils due to the health hazards attributed to the saturated fatty acids. Though various medicinal effects of CO have been reported including the hypolipidemic activity, people are still confused in the consumption of this natural oil....
Published on Aug 1, 2016in Metabolism-clinical and Experimental6.51
Niki Katsiki31
Estimated H-index: 31
(A.U.Th.: Aristotle University of Thessaloniki),
Dimitri P. Mikhailidis74
Estimated H-index: 74
(UCL: University College London),
Christos S. Mantzoros103
Estimated H-index: 103
(BIDMC: Beth Israel Deaconess Medical Center)
Abstract Non-alcoholic fatty liver (NAFLD) is the most common liver disease worldwide, progressing from simple steatosis to necroinflammation and fibrosis (leading to non-alcoholic steatohepatitis, NASH), and in some cases to cirrhosis and hepatocellular carcinoma. Inflammation, oxidative stress and insulin resistance are involved in NAFLD development and progression. NAFLD has been associated with several cardiovascular (CV) risk factors including obesity, dyslipidemia, hyperglycemia, hypertens...
Published on Jun 1, 2016in Plant Foods for Human Nutrition2.60
Olfa Belguith-Hadriche4
Estimated H-index: 4
,
Sonda Ammar8
Estimated H-index: 8
(University of Sfax)
+ 5 AuthorsMohamed Bouaziz27
Estimated H-index: 27
(University of Sfax)
The phenolic constituents of the aqueous-ethanolic extract of Tunisian Ficus carica (F. carica) fruit (FE) and its antihyperlipidemic and antioxidant activities in high-fat diet-induced hyperlipidemic rats (HFD) were evaluated. The obtained results demonstrated that the FE improved the lipid profile by decreasing the total cholesterol, triglyceride, low-density lipoprotein cholesterol and increasing high-density lipoprotein cholesterol levels. It also reduced the content of thiobarbituric acid-r...
Published on Feb 1, 2016in Human & Experimental Toxicology2.17
Ss Nair1
Estimated H-index: 1
(University of Calicut),
Jj Manalil4
Estimated H-index: 4
(University of Calicut)
+ 3 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Virgin coconut oil (VCO) is an unrefined kernal oil, prepared from Cocos nucifera L., having substantial nutritional and medicinal value. Experimental studies have suggested its antioxidant, anti-inflammatory, immunostimulatory and hypolipidemic effects. The present study assesses its effect on formalin-induced chronic inflammation and cyclophosphamide (CTX)-induced systemic toxicity in murine models. Oral administration of VCO effectively reduced formalin-induced paw oedema in mice with more or...
Cited By1
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