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Association of monocyte myeloperoxidase with incident cardiovascular disease: The Atherosclerosis Risk in Communities Study

Published on Oct 9, 2018in PLOS ONE2.776
路 DOI :10.1371/journal.pone.0205310
Abayomi O. Oyenuga1
Estimated H-index: 1
(UMN: University of Minnesota),
David J. Couper74
Estimated H-index: 74
(UNC: University of North Carolina at Chapel Hill)
+ 2 AuthorsAaron R. Folsom159
Estimated H-index: 159
(UMN: University of Minnesota)
Abstract
Myeloperoxidase (MPO) is a heme-containing peroxidase found in azurophilic granules of neutrophils and monocytes. Epidemiological studies have reported greater plasma MPO concentration to be associated with increased incidence of several cardiovascular diseases (CVD), but the association of intracellular monocyte MPO (mMPO) with CVD is unclear. The prospective population-based Atherosclerosis Risk in Communities (ARIC) cohort study measured mMPO using flow cytometry in 1,465 participants. The association of mMPO with incident cardiovascular disease (CVD, comprising incident coronary heart disease (CHD), heart failure, stroke, peripheral artery disease, and cardiovascular mortality) was examined over a median 9.6 years of follow-up (n = 290 CVD events). There was no statistically significant association between mMPO and all incident CVD events in either age, sex, and race-adjusted proportional hazards models (HR (95% CI) across tertiles of mMPO: 1, 1.09 (0.76, 1.57), and 0.78 (0.52, 1.15), P-trend = 0.21) or adjusted for other major CVD risk factors (HR (95% CI): 1, 1.17 (0.81, 1.69), and 0.87 (0.58, 1.29), P-trend = 0.50). There also was no association between mMPO tertiles and incident CHD, heart failure, or all-cause mortality, examined separately. In conclusion, intracellular monocyte myeloperoxidase was not associated with incident cardiovascular disease in this prospective population-based study.
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References37
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#2Andrey V. GrechkoH-Index: 7
Last. Alexander N. Orekhov (RAS: Russian Academy of Sciences)H-Index: 44
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#1Serdal Arslan (Cumhuriyet University)H-Index: 9
#2脰cal Berkan (Cumhuriyet University)H-Index: 9
Last. Eylem Itir Aydemir (Cumhuriyet University)H-Index: 2
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#1Amit Patel (UCL: University College London)H-Index: 12
#2Yan Zhang (St George's, University of London)H-Index: 15
Last. Simon Yona (UCL: University College London)H-Index: 32
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In humans, the monocyte pool comprises three subsets (classical, intermediate, and nonclassical) that circulate in dynamic equilibrium. The kinetics underlying their generation, differentiation, and disappearance are critical to understanding both steady-state homeostasis and inflammatory responses. Here, using human in vivo deuterium labeling, we demonstrate that classical monocytes emerge first from marrow, after a postmitotic interval of 1.6 d, and circulate for a day. Subsequent labeling of ...
131 CitationsSource
#1Yan WangH-Index: 1
#2Xu-Yan ChenH-Index: 1
Last. Xiang-Yang ZhangH-Index: 1
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#1Yan-yan LiH-Index: 3
#2Hui WangH-Index: 7
Last. Xin-zheng LuH-Index: 5
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#1Sailaja Maddhuri (Osmania University)H-Index: 1
#2Priyanka Pallapollu (Osmania University)H-Index: 1
Last. Hema Prasad Mundluru (Osmania University)H-Index: 5
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Introduction. The present investigation is pursued to study the possible association of 鈥463G>A and 鈥129G>A polymorphism in MPO gene and assessment of plasma MPO levels with the risk of developing coronary artery disease. Material and methods. A total of 200 angiographically documented CAD patients and 200 age, gender ethnicity matched healthy controls were recruited for the study. Plasma MPO levels were assessed using enzyme-linked immunosorbent assay (ELISA) kit and genotypes were determined b...
2 CitationsSource
#1Jiyeon Yang (TU: Temple University)H-Index: 2
#2Lixiao Zhang (TU: Temple University)H-Index: 3
Last. Hong Wang (TU: Temple University)H-Index: 39
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Monocytes express various receptors, which monitor and sense environmental changes. Monocytes are highly plastic and heterogeneous, and change their functional phenotype in response to environmental stimulation. Evidence from murine and human studies has suggested that monocytosis can be an indicator of various inflammatory diseases. Monocytes can differentiate into inflammatory or anti-inflammatory subsets. Upon tissue damage or infection, monocytes are rapidly recruited to the tissue, where th...
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#1Cuixian ChangH-Index: 1
#2Baorong Gao (PKU: Peking University)H-Index: 1
Last. Guoqiang JiangH-Index: 1
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Abstract Objectives Genetic polymorphism of human myeloperoxidase (MPO) -463G/A has been implicated to alter the risk of coronary artery disease (CAD), but the results are controversial. To improve the reliability of the conflicting results, we conducted a meta-analysis of studies relating the MPO -463G/A polymorphism with the risk of CAD. Design and methods Two investigators independently searched the MEDLINE, EMBASE and Cochrane Library up to June, 2012. Summary odds ratios (OR) and 95% confid...
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#1Naping Tang (NPU: Northwestern Polytechnical University)H-Index: 4
#2Yan WangH-Index: 1
Last. Qi-Bing Mei (Fourth Military Medical University)H-Index: 2
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Abstract Published data on the association between the myeloperoxidase ( MPO ) G-463A polymorphism and coronary artery disease (CAD) are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis on this topic was performed. PubMed, EMBASE and Chinese national knowledge infrastructure were searched for studies regarding the association between the MPO G-463A polymorphism and CAD. A logistic regression analysis was used to estimate the genetic effect and the possible g...
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#1Claudia NussbaumH-Index: 15
#2Anna KlinkeH-Index: 18
Last. Markus SperandioH-Index: 35
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Abstract Significance: The heme-enzyme myeloperoxidase (MPO) is one of the major neutrophil bactericidal proteins and is stored in large amounts inside azurophilic granules of neutrophils. Upon cell activation, MPO is released and extracellular MPO has been detected in a wide range of acute and chronic inflammatory conditions. Recent Advances and Critical Issues: Apart from its role during infection, MPO has emerged as a critical modulator of inflammation throughout the last decade and is curren...
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#1Simon Correa (Harvard University)H-Index: 1
#1Simon Correa (Harvard University)
Last. Finnian R. Mc Causland (Harvard University)H-Index: 10
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Background Myeloperoxidase (MPO) catalyzes the formation of reactive nitrogen species and levels are elevated in patients with chronic kidney disease (CKD). Although increased oxidative stress and inflammation are associated with progression of CKD and cardiovascular disease (CVD), relationships between MPO concentration, CKD progression, CVD, and death remain unclear. Study Design Prospective cohort. Setting & Participants 3,872 participants from the Chronic Renal Insufficiency Cohort (CRIC) wh...
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#1Liuqing Wang (Anhui Medical University)
#2Yinliang Qi (Anhui Medical University)
Last. Hua-Qing Zhu (LMB: Laboratory of Molecular Biology)H-Index: 8
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Rare studies have been conducted to investigate the exact interactions between lung adenocarcinoma transcript 1 (MALAT1), thymocyte selection-associated high mobility group box (TOX), and miRNAs in the pathogenesis of atherosclerosis (AS). We aim to investigate the crosstalk between MALAT1 and TOX and evaluate whether the regulatory mechanism was associated with the miRNA network. AS tissues were collected to determine the level of MALAT1 expression in AS patients, together with determination of...
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Abstract Myeloperoxidase (MPO) is a member of the superfamily of heme peroxidases that is mainly expressed in neutrophils and monocytes. MPO-derived reactive species play a key role in neutrophil antimicrobial activity and human defense against various pathogens primarily by participating in phagocytosis. Elevated MPO levels in circulation are associated with inflammation and increased oxidative stress. Multiple lines of evidence suggest an association between MPO and cardiovascular disease (CVD...
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