Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance
Abstract
It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces. Here, using human intestinal epithelial cells we could show that although both type I and type III IFNs confer an antiviral state to the cells, they do so with distinct kinetics. Type I IFN signaling is characterized by...
Paper Details
Title
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance
Published Date
Nov 28, 2018
Journal
Volume
14
Issue
11
Pages
e1007420 - e1007420
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