Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study

Objectives Clinical variables were investigated in the ‘treatment resistant depression ( TRD )‐ III ’ sample to replicate earlier findings by the European research consortium ‘Group for the Study of Resistant Depression’ ( GSRD ) and enable cross‐sample prediction of treatment outcome in TRD . Experimental procedures TRD was defined by a Montgomery and Åsberg Depression Rating Scale ( MADRS ) score ≥22 after at least two antidepressive trials....