FUNCTIONALLY GUIDED SUPRAMAXIMAL RESECTION OF IDH-WILDTYPE GLIOBLASTOMAS AND THE EFFECT ON PROGRESSION FREE SURVIVAL

Gross total resection (GTR), defined as complete resection of enhancing tumour on post-operative MRI, increases progression free survival (PFS) in patients with glioblastoma. We have extended the concept of functionally guided supramaximal resection (SMR) where the aim of surgery is to resect up to 2 cm beyond the enhancing tumour in all directions, limited only by functional boundaries. Boundaries are identified by pre-operative diffusion...