5 Defining the effects of genetic variation using machine learning analysis of CMRS: a study in hypertrophic cardiomyopathy and in a healthy population

Introduction

Hypertrophic cardiomyopathy (HCM) is characterised by great phenotypic diversity and broad spectrum of clinical courses. The genetic, environmental and phenotypic determinants of outcome remain poorly understood. We integrated machine-learning analysis of cardiovascular magnetic resonance (CMR) with computational modelling to define the effects of genetic variation on the heart in both HCM patients and heathy volunteers....