SYK inhibitor entospletinib prevents ocular and skin GVHD in mice
Abstract
Graft-versus-host disease (GVHD) is a major complication of hematopoietic stem cell transplantation (HCT). The tyrosine kinase SYK contributes to both acute and chronic GVHD development, making it an attractive target for GVHD prevention. Entospletinib (ENTO) is a second-generation highly selective SYK inhibitor with a high safety profile. Potential utility of ENTO as GVHD prophylaxis in patients was examined using a preclinical mouse model of...
Paper Details
Title
SYK inhibitor entospletinib prevents ocular and skin GVHD in mice
Published Date
Oct 4, 2018
Journal
Volume
3
Issue
19
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