A rapid analysis of piroxicam in beagle plasma applying evaporation-free liquid-liquid extraction by supercritical fluid chromatography-tandem mass spectrometry

Bioequivalence study is highly prized to piroxicam (PIRO), since its generic products have been widely used worldwide. The present work was undertaken to explore the pharmacokinetic behaviors and bioequivalence of two branded PIRO tablets in beagle dogs using the supercritical fluid chromatography tandem mass spectrometry (SFC-MS/MS) method. Here, a fast evaporation-free liquid-liquid extraction (EF-LLE) method using ethyl acetate was developed...