Prospective Evaluation of the ThyroSPEC™ Mutation Panel for the Diagnosis of Indeterminate Thyroid Fine-Needle Aspiration Cytologies

We previously demonstrated the applicability of MALDI-TOF mass spectrometry mutation detection to air-dried fine-needle aspiration (FNA) smears to provide diagnostic information for clinical decision making. The panel was extended to interrogate 81 point mutations and 15 fusions to assess malignancy. This ThyroSPEC™ panel was applied to residual material from 54 indeterminate liquid FNA cytologies (FNACs) with available histology in the region...